%0 Journal Article
%T Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1¦Â and TNF-¦Á expression
%A Guodong Hu
%A Jiawen Lv
%A Junchao Zen
%A Lin Zhang
%A Mengying Xu
%A Min Liu
%A Ping Wang
%A Wen Zhao
%A Xiaoyin Bo
%A Yanxia Liao
%A Yinghua Chen
%A Yiran Li
%A Zheyu Dong
%A Zihao Guo
%J Archive of "American Journal of Translational Research".
%D 2019
%X Angiogenesis is an important step in skin wound repair. Angiogenesis is affected by the functions of many types of cells, especially endothelial cells. Cdc42 plays a vital role in endothelial cell function and vascular development; however, the role of Cdc42 in skin microvascular permeability and skin wound healing is unclear. This study investigated the involvement of Cdc42 in skin wound-healing processes based on its known roles in angiogenesis. Full-thickness skin wounds were created on wild-type and inducible vascular-endothelial-specific Cdc42-/- mice. Cdc42 deletion in endothelium affected wound healing in following ways. Reepithelialization of wounds in Cdc42-/- mice was delayed compared with that of wounds in wild-type mice. The degree of angiogenesis of wound granulation tissue was significantly lower in Cdc42-/- mice than in wild-type mice. Infiltration of F4/80+ macrophages and the expression of MCP-1, IL-1¦Â, and TNF-¦Á were increased in the wound bed of Cdc42-/- mice compared with wild-type mice. These results confirm that Cdc42 in endothelium is required for angiogenesis and is an essential regulator of key skin wound-healing processes
%K Cdc42
%K skin wound
%K angiogenesis
%K reepithelialization
%K inflammation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357328/