%0 Journal Article
%T Effects of neoadjuvant laparoscopic hyperthermic intraperitoneal chemoperfusion and intraperitoneal/systemic chemotherapy on peritoneal metastasis from gastric cancer
							| Journal of Peritoneum (and other serosal surfaces)
%A Akiyoshi Mizumoto
%A Emel Canbay
%A Haruaki Ishibashi
%A Kazuyoshi Takeshita
%A Keizou Taniguchi
%A Kousuke Noguchi
%A Masamitu Hirano
%A Masumi Ichinose
%A Nobuyuki Takao
%A Satoshi Wakama
%A Shouszou Sako
%A Takuji Fujita
%A Yan Li
%A Yang Liu
%A Yutaka Yonemura
%J Journal of Peritoneum (and other serosal surfaces)
%D 2017
%R https://doi.org/10.4081/joper.2017.60
%X Our aim was to clarify the effects of neoadjuvant hyperthermic intraperitoneal chemoperfusion (NLHIPEC) followed by intraperitoneal/systemic chemotherapy (NIPS) on peritoneal metastasis from gastric cancer. After carrying out exploratory laparoscopy to determine the peritoneal cancer index (pretreatment PCI: Pre-PCI) in 150 patients, we performed NLHIPEC for 60 min. with peritoneal port placement: a series of 3-week cycles of NIPS using S1, docetaxel, and cisplatin two weeks after NLHIPEC: performed cytoreductive surgery in 86 patients four weeks after NIPS, and subsequently measured PCI (Post-PCI). Positive cytology in 38 patients changed to negative in 26 (68.4%) patients at laparotomy. The post-PCI (6.7¡À7.8) was significantly lower than the pre-PCI (10.6¡À10.2) (P=0.0001). The PCI was ¡Ý14 in 30 patients at pretreatment and ¡Ü13 in 19 (63.3£¿£¿) of these patients at posttreatmjent. Post-PCI cut-off level (¡Ü13 vs ¡Ý14) and cytology after NIPS (negative vs positive) emerged as independent indicators of prognosis. Postoperative mortality was 1.2% (1/86). NLHIPEC and NIPS are safe and effective modalities for reducing Post-PCI below the cut-off level and eradicating peritoneal free cancer cells
%K Gastric cancer
%K peritoneal metastasis
%K Peritoneal metastasis
%K hyperthermic intraperitoneal chemoperfusion
%K Hyperthermic intraperitoneal chemoperfusion
%K laparoscopy
%K Laparoscopy
%K peritoneal cancer index
%K Peritoneal cancer index
%U http://www.jperitoneum.org/index.php/joper/article/view/60