%0 Journal Article
%T GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location
							| European Journal of Histochemistry
%A Ant£¿nio F. da Silva-filho
%A Luiza R. Amorim Lima
%A Maira G. da Rocha Pitta
%A Maria de F¨¢tima Deodato de Souza
%A Marina Ferraz Cordeiro
%A Mario R. Martins
%A Michael W.L. Quirino
%A Moacyr J.B. de Melo R¨ºgo
%A M¨¢rio S. de Souza Albuquerque
%J European Journal of Histochemistry
%D 2018
%R https://doi.org/10.4081/ejh.2018.2931
%X Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer
%K Gastric adenocarcinoma
%K polypeptide N-acetylgalactosaminyltransferases
%K clinical-pathological analyses
%K immunohistochemistry.
%U https://www.ejh.it/index.php/ejh/article/view/2931