%0 Journal Article
%T Appearance of ¦Â-dystroglycan precedes the formation of glio-vascular end-feet in developing rat brain
							| European Journal of Histochemistry
%A Erzs¨¦bet Oszwald
%A Istv¨¢n Adorj¨¢n
%A Mih¨¢ly K¨¢lm¨¢n
%J European Journal of Histochemistry
%D 2018
%R https://doi.org/10.4081/ejh.2018.2908
%X Dystroglycan has an important role in binding of perivascular glial end-feet tothe basal lamina. Its ¦Â-subunit is localized in the glial end-feet. The investigation period lasted from E(embryonic day)12 to E20. Laminin and ¦Â-dystroglycan were detected by immunohistochemistry, the glial localization of the latter one was supported by electron microscopy. The immatureglial structures were visualized by the immunostaining of nestin. The ¦Â-dystroglycan immunoreactivity appeared at E16 following the laminin of basal lamina but preceding the perivascular processes of radial glia (E18) and astrocyte-like cells (E20). It occurred in cell bodies which attached to the vessels directly but not with vascular processes and end-feet. The presence of ¦Â-dystroglycan in such immature cells may promote their differentiation to perivascular astrocytes and influence the formation of the glio-vascular processes
%K Brain development
%K dystroglycan
%K glial end-feet
%K glio-vascular
%K nestin.
%U https://www.ejh.it/index.php/ejh/article/view/2908