%0 Journal Article
%T Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men
%A Ali Bakhti
%A Amir Feily
%A Marigdalia K. Ramirez-Fort
%A Masoomeh Hosseinpoor
%A Mohamad Nekuyi
%A Reza Sahraei
%A Saeed Sobhanian
%A Zahra Fathinezhad
%J -
%D 2016
%R https://doi.org/10.4081/dr.2016.6386
%X The etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible positive predictive value of 2D:4D in the development of AGA. We performed a single-site, descriptive-analytical study among a racially homogeneous population. Our results revealed that no significant association was determined between right 2D:4D and AGA severity within our entire population (P=0.384, r=0.025), however a positive correlation coefficient was identified in subjects above the age of 40. Based on the receiver operating characteristic curve analysis, 2D:4D does not predict the development of AGA. AGA is truly a multifactorial disease. Further, our findings suggest that increased in utero exposure to androgens as a fetus does not predispose men to develop AGA.
%U https://www.pagepress.org/journals/index.php/dr/article/view/6386