%0 Journal Article
%T A simpler diagnostic method using blood collection on filter paper to determine anti-natural octyl disaccharide-leprosy infectious disease research institute diagnostic in household contacts of leprosy patients
							| Dermatology Reports
%A Anisha Callista Prakoeswa
%A Bagus Haryo Kusumaputra
%A Bayu Bijaksana Rumondor
%A Dinar Adriaty
%A I. Iswahyudi
%A Indropo Agusni
%A Malcom Duthie
%A Meva Nareza Trianita
%A Muhamad Yulianto Listiawan
%A Shinzo Izumi
%J Dermatology Reports
%D 2019
%R https://doi.org/10.4081/dr.2019.8048
%X The high prevalence among children shows continued transmission from adult and lack of disease control by the health system. Detection of anti-NDO-LID-1 has been known to be more effective to predict the development of leprosy in household contacts than just detecting PGL-1 or LID- 1 alone. However, serodiagnosis is not available in poorer-settings area and the procedure (venepuncture) is still inconvenient to some people. These problems can be solved by using finger-prick blood sample on filter paper. This study aims to prove the effectiveness of using capillary blood samples on filter paper to detect the positivity of Ig G antibody against NDO-LID-1 antigen in asymptomatic household contacts. Seventeen samples of capillary blood on filter paper and sera were tested for IgG anti-NDO-LID-1 using ELISA. There was no significant difference between IgG level from filter paper and serum (p=0.754) and there was also a strong positive correlation (R=0.906) between the two procedures. These findings show that the use of filter paper and NDO-LID-1 is worthy of further investigations, especially for those with lower bacillary load or contacts of leprosy patients
%K leprosy
%K household contacts
%K IgG Anti NDO-LID-1
%K filter paper
%U https://www.pagepress.org/journals/index.php/dr/article/view/8048