%0 Journal Article
%T Intravesical administration of combined hyaluronic acid and chondroitin sulfate can improve symptoms in patients with refractory bacillus Calmette-Guerin-induced chemical cystitis: Preliminary experience with one-year follow-up
							| Archivio Italiano di Urologia e Andrologia
%A Ciro Imbimbo
%A Ferdin
%A Lorenzo Spirito
%A Massimiliano Creta
%A Nicola Longo
%A Roberto Buonopane
%A Sergio Di Meo
%A Vincenzo Mirone
%A Vittorio Imperatore
%A o Fusco
%J Archivio Italiano di Urologia e Andrologia
%D 2018
%R https://doi.org/10.4081/aiua.2018.1.11
%X Objective: We investigated the efficacy of intravesical instillations of combined hyaluronic acid (HA) and chondroitin sulphate (CS) in patients with bacillus Calmette-Gu¨¦rin (BCG)-induced chemical cystitis unresponsive to first-line therapies. Patients and methods: We retrospectively reviewed the clinical records of patients with grade 2 BCG-induced chemical cystitis unresponsive to first line therapeutic options performed according to the International Bladder Cancer Group guidelines who underwent intravesical instillations of HA/CS. Bladder pain, urinary urgency, voiding volume and number of voids/24 hours recorded prior to treatment, at the end of the treatment, at six months and at one-year follow-up were recorded and analyzed. Results: The records of 20 patients were identified. All patients underwent eight weekly instillations of HA/CS. Mean baseline visual analogue scale (VAS) scores ¡À Standard Deviation (SD) for urinary urgency and bladder pain were 7.8 ¡À 0.5 and 7.2 ¡À 1.0, respectively. Mean number of voids/24 hours ¡À SD was 15.4 ¡À 2.3 and mean urine volume per void ¡À SD was 85.8 ¡À 21.0 mL. At the end of the treatment, mean VAS scores ¡À SD for urgency and pain significantly decreased to 4.7 ¡À 1.1 and 4.2 ¡À 0.9, respectively (p < 0.05 in both cases). Mean number of voids/24 hours ¡À SD decreased to 9.6 ¡À 1.4 (p < 0.05) and mean urine volume per void ¡À SD significantly increased to 194.1 ¡À 59.5 mL (p < 0.05). At six months and one-year followup, all outcome measures remained stable. Conclusions: Bladder instillations of HA/CS provide significant and durable improvement of bladder pain, urinary urgency, urinary volume per void and urinary frequency in patients with refractory BCG-induced chemical cystitis
%K Bacillus Calmette-Gu¨¦rin
%K Bladder cancer
%K Chondroitin sulphate
%K Cystitis
%K Hyaluronic acid
%U https://www.pagepressjournals.org/index.php/aiua/article/view/aiua.2018.1.11