%0 Journal Article
%T Troponin T as a Diagnostic Marker in the Detection of Acute Myocardial Infarction at Autopsy SciDoc Publishers | Open Access | Science Journals | Media Partners
%A Richard Flavin
%A Kathleen Han
%J Forensic Science & Pathology (IJFP)
%D 2018
%R http://dx.doi.org/10.19070/2332-287X-140009
%X Sudden cardiac death due to an acute myocardial infarction (AMI) comprises a significant proportion of autopsy cases. In clinical practice, AMI is diagnosed with the aid of the electrocardiogram and serum biochemical markers specific in the detection of myocardial damage [1-3]. Troponin T and Troponin I in particular have been extensively studied and proof of sensitivity and specificity in detecting AMI is well established [3-6]. Troponin is a complex of three regulatory proteins (Troponin C, I and T) that is integral to muscle contraction in skeletal and cardiac muscle [7]. It is a component of thin filaments along with actin and tropomyosin and is the protein to which calcium binds to accomplish regulation of contraction and relaxation of the cardiac muscle. During myocardial injury, as seen in AMI, Troponin is released from the injured myocyte into the circulation which can be detected biochemically. The potential role however of Troponin in the diagnosis of AMI at post-mortem is less well known [8-10]. In this study, we evaluate the sensitivity and specificity of Troponin T as a diagnostic tool in the detection of AMI at autopsy
%K n/a
%U https://scidoc.org/IJFP-2332-287X-02-401.php