%0 Journal Article
%T Possible Protective Effect of Pumpkin Seed Oil against Sodium Nitrite in Rats; A Biochemical and Genetic Study SciDoc Publishers | Open Access | Science Journals | Media Partners
%A Abdelzaher WY
%A Ali DM
%J Clinical Pharmacology & Toxicology (IJCPT)
%D 2018
%R http://dx.doi.org/10.19070/2167-910X-1700044
%X Abstract Objective: The aim of our study was to test the protective effect of pumpkin seed oil against sodium nitrite toxicity in rats. Methods: Forty eight adult male albino rats were divided into 4 groups. The rats were administered daily 100 mg/kg/day sodium nitrite in presence/absence of 1.5 ml/kg/day pumpkin seed oil for 5 weeks. Results: The results indicated that sodium nitrite induced oxidative stress, lipids profile disorders, DNA damage and chromosomal abnormalities. The pumpkin seed oil has antioxidant effect; it improved levels of total antioxidant capacity, malondialdehyde and lipids profile. It also has antimutagenic effect; it decreased the DNA damage and structural chromosomal abnormalities. Conclusion: Pumpkin seed oil can ameliorate the toxic effects induced by sodium nitrite
%K n/a
%U https://scidoc.org/IJCPT-2167-910X-06-203.php