%0 Journal Article
%T The Detection of Serum and Urine Levels of Alpha 2-Macroglobulin in Nasopharyngeal Carcinoma Patients Receiving Late Period Radiotherapy and its Significance
%A Cao W
%A Fang S
%A Ge Y
%A Kong X
%A Li H
%A Liu Y
%A Wang S
%A Zhang Z
%A Chen X
%J Dentistry and Oral Science
%D 2018
%R http://dx.doi.org/10.19070/2377-8075-18000119
%X Objective: To detect the dynamic changes of the serum and urine alpha2-macroglobulin (¦Á2M) in patients with nasopharyngeal carcinoma after receiving different doses of ionizing radiation and to provide further basis of ¦Á2M application in the diagnosis and treatment of osteoradionecrosis of the jaws (ORNJ). Methods: We use ELISA to further identify the expression of ¦Á2M in the serum and urine of 30 patients with nasopharyngeal carcinoma after receiving different doses (0Gy, 50Gy, 70Gy) of ionizing radiation and 20 healthy volunteers. Data were compared t test using 17.0 software package. Results: The serum level of ¦Á2M in patients with nasopharyngeal carcinoma has positive correlation tendency with radiation dose. Compared with the experimental groups (0Gy and 50Gy), the serum ¦Á2M level of the experimental group (70Gy) increased significantly (P<0.01). There was no statistically significant difference (P>0.05) among the urine level of ¦Á2M in patients receiving different doses of radiation. Conclusion: (1) It prompts that serum ¦Á2M may be regarded as one of the early indicators monitoring the jaw damage from ionizing radiation. There should be more in-depth and systematic studies. (2) The urine level of ¦Á2M in patients with nasopharyngeal carcinoma has nothing to do with radiation doses and we consider that radiation within therapeutic doses has no obvious effect on ¦Á2M kidney metabolism
%K n/a
%U https://scidoc.org/IJDOS-2377-8075-05-301.php