%0 Journal Article
%T Dietary Epigenetic Factors Influencing Central Obesity SciDoc Publishers | Open Access | Science Journals | Media Partners
%A Fern
%A Telles S
%A es D
%J Medical Biotechnology & Genetics (IJMBG)
%D 2018
%R http://dx.doi.org/10.19070/2379-1020-160008
%X Abstract Background: Central obesity, a major public health concern in the Asia-Pacific region, is a result of genetic predisposition as well as epigenetic influences. Nutritional factors influence obesity, through the calorie intake and modulating gene expression. Objectives: To conduct a systematic review of the efficacy of dietary interventions through clinical trials, in the management of obesity. Methods: PubMed and Google Scholar databases were searched for 20 years ending December 30, 2014, to find metaanalyses, systematic reviews, and randomized, placebo-controlled studies for central obesity-related clinical trials. The search terms were ˇ°central obesityˇ± and ˇ°dietary interventionsˇ± or ˇ°calorie recommendationˇ±. All clinical trials on the effects of dietary interventions with the key outcome measures as change in BMI, waist-hip circumference and body fat were included. Results: Several dietary regimens with varying macronutrients composition are used to combat obesity, such as low-calorie diets, very low-calorie diets (VLCD), low-fat diets, high-fiber diets, low-carbohydrate diets, low glycemic index (GI) diets and plant-based diets. However, very low-calorie-ketogenic and high protein diets have demonstrable significant adverse health effects. Conclusion: The studies reviewed show promise of benefits with changes in epigenetic dietary factors. To draw definite conclusions, there is a need for more long-term studies, with larger sample sizes; and clinical interventions trials, to minimize the risk of false positives and confounding factors influencing the results
%K n/a
%U https://scidoc.org/IJMBG-2379-1020-04-301.php