%0 Journal Article
%T Superparamagnetic Iron Oxide Nanoparticles (SPIONS): The King in The Cosmos of Multimodal Onco¨CNanotheranostics SciDoc Publishers | Open Access | Science Journals | Media Partners
%A SishirK Kamalapuram
%A Jagat R Kanwar
%J Nano Studies & Technology (IJNST)
%D 2018
%R http://dx.doi.org/10.19070/2167-8685-130003e
%X There is an extensional necessity for the major amelioration of hybrid multimodal nanotheranostics, that can offer ulterior theranostic possibilities in the field of nano-oncology [1,2]. Novel class of nanotheranostic medicines certainly warrant more throughput therapeutic abilities in comparison with conventional platforms [3]. One such platform that dawned in the era of existing treatment efficacies is superparamagnetic iron oxide nanoparticles (SPIONS) nanotheranostics[4]. SPIONS are approved by food and drug administration, USA (FDA), safe, biocompatible and exhibit astounding capabilities in prominence,in realms of (1) diagnostic and prognostic platforms ¨C nanofluidic lap on chip devices, nanoarray systems, nanosensors [5], (2)targeted multimodal drug delivery and live imaging strategies ¨C pH responsive drug release [6], tumour oxygen and hypoxic sensors [7], locked nucleic and chimeric aptamer conjugates [8],fluorescence and bioluminescence approaches [9], ribonucleic acid interference (RNAi) technology [10], antibodies [11], nanobodies [12], magnetic guided therapy [13], sonophoto dynamic therapy (SPDT) ¨C ultrasound and infrared laser [14], photodynamic therapy (PDT)[15], photothermal therapy (PTT)[15], radio imaging and therapy(RIT)[14], photoacoustic imaging(PAI)[16], magnetic resonance imaging and ultrasound therapy (MRI + US)[17], positron emission tomography(PET) [18], single-photon emission computed tomography (SPECT)18.In turn, variant therapeutic abilities of SPIONS congregate to offer interactive therapeutic feedback monitoring over a time period, opening new vistas for personalised cancer nanomedicine[19]. Having a closer look at the conventional treatment regimes including chemotherapy, immunotherapy, it is a poignant fact that, these platforms certainly lack imaging ability, disqualifying them from being a theranostic [3]. Furthermore, existing radio therapeutic platforms that fall in basket of current theranostic medicine are extremely toxic and even trigger recurrent cancers leading to drug resistance [20].This is where; SPIONS are conquering the therapeutic ground exhibiting versatility in derivatizing combinational drug systems both with chemotherapeutic and natural product derived compounds (neem, curcumin, milk derived proteins) [21]. SPIONS are well known for their exceptional superparamagnetic ability with high relaxivity, outstanding bio degradability, targeted delivery, moreover can be easily integrated with a myriad of drug delivery platforms, achieving multimodal action [22]. Hence, SPIONS are extensively utilised as
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%U https://scidoc.org/IJNST-2167-8685-02-001e.php