%0 Journal Article
%T 脂肪酸结合蛋白5和细胞维甲酸结合蛋白2在脑胶质瘤中的表达
%A 叶飞
%A 曾令成
%A 郭东生
%A 雷霆
%A 韩林
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.03.007
%X 摘要 目的 探讨脂肪酸结合蛋白5（fatty acid-binding protein 5，FABP5）与细胞维甲酸结合蛋白2（cellular retinoic acid-binding protein 2，CRABP2）在脑胶质瘤中的表达及与脑胶质瘤病理级别、维甲酸治疗抵抗的关系。方法 应用免疫组织化学染色法检测125例脑星型细胞瘤组织中FABP5及CRABP2蛋白表达。全反式维甲酸作用前后，以Brdu-ELISA法检测胶质瘤细胞增殖，并以实时荧光定量PCR检测胶质瘤细胞株中FABP5及CRABP2在mRNA水平的表达。结果 FABP5阳性细胞比例在WHO Ⅱ级星型细胞瘤中占（16±9）%，Ⅲ级中占（33±22）%，Ⅳ级中占（50±29）%，FABP5蛋白表达与胶质瘤病理级别呈显著正相关（P<0.05）。CRABP2阳性细胞比例在Ⅱ级星型细胞瘤中占（46±12）%，WHO Ⅲ级中占（30±15）%，Ⅳ级中占（10±9）%，CRABP2蛋白表达与胶质瘤病理级别呈显著负相关（P<0.05）。全反式维甲酸促进了胶质瘤细胞株的增殖，全反式维甲酸作用后胶质瘤细胞FABP5 mRNA表达显著上调，而CRABP2显著下调。 结论 FABP5及CRABP2的异常表达与胶质瘤恶性程度相关，并可能介导了胶质瘤细胞对维甲酸的分化抵抗效应
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%U http://www.zlfzyj.com/CN/abstract/abstract8440.shtml