%0 Journal Article
%T 细胞减灭术加腹腔热灌注化疗治疗卵巢癌腹膜转移癌的临床研究
%A 于洋
%A 姬忠贺
%A 孙建华
%A 李雁（：并列第一作者）
%A 武海涛
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.04.009
%X 摘要 目的 研究细胞减灭术（CRS）加腹腔热灌注化疗（HIPEC）治疗卵巢癌腹膜转移癌的疗效及安全性。方法 46例晚期（A组，FIGO Ⅲc/Ⅳ期，n=16和复发性，B组，n=30）卵巢癌腹膜癌患者接受了CRS+HIPEC治疗，分析其临床资料，主要终点指标为总生存期，次要指标为安全性。结果 A、B两组患者的中位总生存期（OS）分别为74.0月和57.5月（P=0.68）。腹膜癌指数（PCI）≤20（n=24）和＞20（n=22）的中位OS分别为76.6和38.5月（P=0.01）。CC 0~1分和CC 2~3分的中位OS分别为79.5和24.3月（P=0.00）。对复发性卵巢癌腹膜癌患者来说，铂类敏感型和耐药型患者的中位OS分别为6 5 . 3 和2 0 . 0 月（P=0.05）。无围手术期死亡病例，5例患者出现术后并发症。多因素分析显示，CC 0~1分、术后化疗≥6周期为改善生存的独立预后因素。结论 CRS+HIPEC可延长卵巢癌腹膜癌患者的总生存期，安全可行
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%U http://www.zlfzyj.com/CN/abstract/abstract8730.shtml