%0 Journal Article
%T 阿帕替尼联合紫杉醇不同时序给药治疗肺癌的实验
%A 丁瑞麟
%A 傅少志
%A 王永莎
%A 范娟
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.07.004
%X 摘要 目的 观察阿帕替尼联合紫杉醇不同时序给药对肺癌的抗肿瘤效应。方法 建立裸鼠A549肺癌模型，随机分成6组。A：0.9%氯化钠溶液组（0.9%NS, d1~8）。B：单用阿帕替尼组（APa, d1~7）。C：单用紫杉醇组（PTX, d1）。D：联合用药组1（C1组：PTX, d1；APa, d2~8）。E：联合用药组2（同时用药组，C2组：PTX, d1；APa, d1~7）。F：联合用药组3（C3组：APa，D1~7；PTX, d8），治疗结束次日行PET/CT扫描测肿瘤组织SUV值、ELISA检测血中VEGFR-2浓度、免疫组织化学检测肿瘤组织微血管计数、TUNEL法检测肿瘤组织细胞凋亡，绘制肿瘤生长曲线，计算肿瘤抑制率。结果 治疗组移植瘤生长速率较0.9%氯化钠溶液组均有所减慢（P<0.05），联合用药组间抑瘤率差异无统计学意义，联合用药组2凋亡细胞数最多，VEGFR-2浓度、SUV值最低（P<0.05），联合用药组2 MVD-CD31表达最低，与除联合用药组3外的其余各组比较，差异均有统计学意义（P<0.05）。结论 阿帕替尼联合紫杉醇同时用药对肺癌治疗效果最好
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%U http://www.zlfzyj.com/CN/abstract/abstract8789.shtml