%0 Journal Article
%T FOLFOX和FOLFOXIRI方案在结直肠癌肝转移术后患者中的应用
%A 杨家和
%A 葛乃建
%A 邵棋
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.11.019
%X 摘要 目的 比较FOLFOXIRI（folinic acid, 5-fluorouracil, oxaliplatin and irinotecan）和FOLFOX（folinic acid, 5-fluorouracil and oxaliplatin）两种化疗方案在肠癌肝转移同期手术切除患者中的有效性及安全性。方法 回顾性分析2008年1月至2011年7月结直肠癌伴肝转移同期手术切除患者60例，分为两组，分别接受FOLFOXIRI或FOLFOX两种化疗方案，观察不良反应以及1、2、3年无病生存期（DFS）和总生存期（OS），采用Kaplan-Merier进行生存分析。结果 接受FOLFOXIRI或FOLFOX两种化疗方案的60例患者，不良反应包括白细胞下降、血小板下降、贫血、恶心呕吐、腹泻、肝肾功能损害、神经毒性、口腔黏膜炎、脱发，FOLFOXIRI组在白细胞减少及腹泻方面有更高的不良事件发生率，其余不良反应与FOLFOX组相仿。两组患者1、2、3年无病生存率分别为73.3%、43.3%、26.7%和60%、13.3%、10%，其中2、3年DFS存在统计学差异。两组患者1、2、3年总生存率分别为86.7%、73.3%、36.7%和83.3%、50%、13.3%，其中3年OS差异有统计学意义（P=0.024）。结论 FOLFOXIRI和FOLFOX两种化疗方案安全有效，FOLFOXIRI组在白细胞减少及腹泻方面有更高的不良事件发生率，但更具远期生存优势
%K 结直肠肿瘤
%K 奥沙利铂
%K 伊立替康
%K 辅助化疗
%K Effect of Neoadjuvant Chemotherapy Cycles on Pathologic Complete Response Rate Under Different Estrogen Receptor Status of Breast Cancer
%K UGCG is Involved in Oxaliplatin Resistance Mechanism of Human Colon Cancer Through Regulating MDR1/P-gp Expression
%K Efficacy and Safety of Weekly Liposome-paclitaxel or Oxaliplatin Combined with Tegafur on Elderly Advanced Gastric Cancer
%K Effects of Different Doses of Bevacizumab on Irinotecan Distribution in Nude Mice Bearing Human Colon Cancer Cell Xenografts
%K Research Progress of Neoadjuvant Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma
%K Valuation of SUVmax
%K Ki-67
%K p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients
%K Platinum Resistance after Neoadjuvant Chemotherapy Interval Debulking Surgery Compared with Primary Debulking Surgery on Patients with Advanced Epithelial Ovarian Carcinoma
%K Tumor-infiltrating Lymphocytes Predict Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma
%K 原发性乳腺癌分子分型与新辅助化疗疗效及预后的相关性
%K Concurrent IMRT Hyperfraction Radiochemotherapy Combined with Adjuvant Chemotherapy on Elderly Patients with Locally Advanced Esophageal Cancer
%K Tanshinone ⅡA Inhibits Nerve Growth Factor Expression in Rats with Oxaliplatininduced Peripheral Neuropathy
%K Effect of Oxaliplatin on CD44V6
%K VEGF
%K survivin
%K Caspase-3 and Caspase-7 in Dimethylhydrazine-induced Colon Cancer Rats
%K Comparison of Efficacy and Prognosis of Oxaliplatin-based Regimens and FOLFIRI Regimen as First-line Chemotherapy for Stage Ⅳ Colorectal Cancer Patients with Different K-ras Statuses
%K Curative Effect of DOF Combined with Thalidomide Regimen and DOF Regimen Alone as First-line Treatment for Advanced Gastric Cancer
%K Therapeutic Effect of Raltitrexed or Fluorouracil plus Irinotecan as Second-line#br# Treatment for Advanced Colorectal Cancer
%U http://www.zlfzyj.com/CN/abstract/abstract8642.shtml