%0 Journal Article
%T 三阴性乳腺癌的分子分型及应用
%A 周茜
%A 王艺蓁
%A 祖旭宇
%A 谭莉
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.03.019
%X 摘要 三阴性乳腺癌是指雌激素受体、孕激素受体及人表皮生长因子受体均为阴性表达的一类乳腺癌，它是一类具有独特生物学及临床特征的乳腺癌亚型，具有进展快、复发早及预后差的特点。根据三阴性乳腺癌的分子特性，可将其分为六种基因表达亚型。研究表明三阴性乳腺癌基因表达亚型和特定的基因突变亚型之间存在重要关联，这一发现可能为不同亚型的三阴性乳腺癌的个体化治疗提供重要的治疗靶点。本文将概括目前对于三阴性乳腺癌亚型分类的认识，以及这种分类在将来临床实践中的应用
%K 三阴性乳腺癌
%K 基因表达亚型
%K 临床应用
%K Analysis E-cad and VEGF Expression in Triple-negative Breast Cancer of Han and Uygur
%K Correlation Between Epithelial-mesenchymal Transition and Sensitivity to EGFR Targeted Monoclonal Antibody in Triple Negative Breast Cancer Cells
%K Establishment of DDP Resistant Variant of Triple Negative Breast Cancer Cell Line MDA-MB-231/DDP and Its Appraisal
%K Clinical Efficacy and Toxicities of Oxaliplatin plus S-1(SOX) and Gemcitabine plus Cisplatin (GP) Regimens on Advanced Triple-negative Breast Cancer Patients
%K Valuation of SUVmax
%K Ki-67
%K p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients
%K Research Status of Estrogen Receptor GPER in Breast Cancer
%K Beclin 1 Protein Enhances Sensitivity of Triple-negative Breast Cancer Cell Line BT-549 to 5-Fu by Promoting Cell Apoptosis
%K Molecular Stratification and Targeted Therapy for Triple-negative Breast Cancer
%K Clinicopathologic Features of Triple Negative Breast Cancer and Their Correlation with Drug-sensitive Protein
%K Retrospective Analysis of Capecitabine in Routine Treatment of Advanced Triple#br# Negative-breast Carcinoma
%K Inhibitory Effect of Celecoxib on Triple-negative Breast Cancer Stem Cells in vitro
%K Clinical Characteristics and Prognosis A Comparative Study between Triple-negative and Non-triple-negative Breast Cancer
%K Treatment of Vinorelbine Plus Cisplatin to Metastatic Triple-negative Breast Cancer with Anthracycline and(or) Taxane-resistance
%K Analysis of Chinicopathological Characteristics and Prognosis of Triple Negative Breast Cancer
%U http://www.zlfzyj.com/CN/abstract/abstract8452.shtml