%0 Journal Article
%T 组织多肽抗原联合ProGRP、CEA、NSE、SCC、CYFRA21-1在肺癌诊治中的价值
%A 喻晶
%A 朱毅
%A 王堃
%A 裴锋
%A 雷旦生
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.05.015
%X 摘要 目的 评估组织多肽抗原（TPA）联合ProGRP、CEA、NSE、SCC、CYFRA21-1在肺癌诊断与疗效监测中的应用价值。方法 用化学发光法和电化学发光法检测238例肺癌患者、25例肺部良性疾病患者及65名健康对照者血清中的TPA、ProGRP、NSE、SCC、CYFRA21-1和CEA水平，并对33例肺癌患者进行随访检测。同时用SPSS19.0统计软件及接受器工作性能曲线（ROC）分析，评价肿瘤标志物的临床应用价值。结果 肺癌患者血清TPA水平（中位数为130.45 U/L）明显高于肺部良性疾病患者（中位数为82.21 U/L）和健康对照组（中位数为70.96 U/L）（P=0.000, 0.002）。根据ROC曲线分析，TPA检测肺癌的临界值为130 U/L，敏感度为50%，特异性为88.9%，相比于其他肺癌标志物( ProGRP、NSE、SCC、CYFRA21-1、CEA），敏感度较高，特异性稍低。肺癌患者血清TPA水平及阳性率随着肿瘤分期的升高而升高（P均<0.05）。TPA水平与疗效也密切相关，临床治疗有效时TPA下降，而病情恶化或出现转移时则升高。各种组合检测中，以六项组合诊断肺癌的敏感度和有效性最高。结论 TPA联合ProGRP、CEA、NSE、SCC、CYFRA21-1测定在肺癌的诊断、疗效及监测复发转移中，具有一定的临床价值
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%U http://www.zlfzyj.com/CN/abstract/abstract8495.shtml