%0 Journal Article
%T 肺癌上皮间质转化后引发Nrf2介导的多药耐药的研究
%A 丁军利
%A 万小蔹
%A 崔小川
%A 朱建荣
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.05.002
%X 摘要 目的 探讨肺癌中上皮间质转化通过Nrf2通路导致多药耐药的可能性。方法 TGF-β1诱导肺腺癌细胞发生上皮间质转化， Western blot法检测癌细胞发生上皮间质转化的标志分子和细胞核内Nrf2的表达变化；比色法测定GSH含量及GST活力的变化；MTT实验检测癌细胞发生上皮间质转化前后对顺铂耐药指数的变化。结果 TGF-β1使癌细胞发生了上皮间质转化：细胞失去极性，上皮标志分子E-cadherin表达下降，而间质标志分子Vimentin和Snail表达上升；细胞发生上皮间质转化后细胞核内Nrf2表达显著增加，GSH含量增高及GST活力增强，癌细胞对顺铂的耐药指数是原来的7.7倍。结论 肺癌上皮间质转化后可能通过Nrf2通路介导了癌细胞的多药耐药
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%U http://www.zlfzyj.com/CN/abstract/abstract8482.shtml