%0 Journal Article
%T 123例原发韦氏环弥漫大B细胞淋巴瘤临床特征与预后分析
%A 宋腾
%A 李书苹
%A 李静敏
%A 梁绍平
%A 王华庆
%A 陈海珠
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.05.013
%X 摘要 目的 探讨原发韦氏环弥漫大B细胞淋巴瘤（Waldeyer’s ring diffuse large B-cell lymphoma, WR-DLBCL）的临床特征、预后因素及治疗策略。方法 回顾性分析天津医科大学肿瘤医院2006年1月至2014年6月收治的123例初治原发韦氏环DLBCL患者，对其临床特征、治疗方式及生存情况比较分析，Kaplan-Meier法计算3、5年生存率，Log rank检验单因素分析，Cox比例风险模型多因素分析。结果 123例患者中位年龄为56岁（16~80岁），男72例。Ann Arbor分期：Ⅰ期20例，Ⅱ期63例，Ⅲ期23例，Ⅳ期17例。中位随访54月，3年和5年生存率分别为74.7%和56.3%，早期（Ⅰ/Ⅱ期）患者3年和5年生存率分别为84.2%和69.4%。单因素分析显示：年龄、体质状况、B症状、临床分期、国际预后指数（IPI）、乳酸脱氢酶（LDH）水平、近期疗效是影响预后的主要因素；多因素分析显示：IPI评分和近期疗效为独立预后因素。结论 原发韦氏环DLBCL多为早期，肿瘤负荷较轻，生存率较高，多数可长期生存。IPI评分和近期疗效是独立预后因素
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%U http://www.zlfzyj.com/CN/abstract/abstract8751.shtml