%0 Journal Article
%T 小分子化合物PHA-767491对白血病K562细胞抑制增殖和诱导凋亡的作用
%A 张丽沙
%A 张宁波
%A 彭朝阳
%A 李伟
%A 汪珊珊
%A 陈丽芳
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.03.006
%X 摘要 目的 探讨PHA-767491对白血病细胞K562的抑制能力及分子机制。方法 采用不同浓度的PHA-767491作用于K562细胞，利用MTT法在不同的时间点检测细胞存活率，RT-PCR及Western blot检测PHA-767491诱导的凋亡信号途径，hochest染色及流式细胞术检测K562的凋亡水平。结果 PHA-767491显著抑制K562细胞的增殖，进一步结果表明PHA-767491可以显著下调抗凋亡蛋白Xiap和Mcl-1蛋白的表达水平，诱导K562细胞通过Caspase途径进入凋亡。结论 PHA-767491可以通过诱导K562细胞凋亡而显著抑制其增殖，为今后的白血病治疗提供了一种新的备选药物
%K Cdc7激酶
%K PHA-767491
%K K562
%K 凋亡
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%U http://www.zlfzyj.com/CN/abstract/abstract8439.shtml