%0 Journal Article
%T 酸性富含半胱氨酸分泌型蛋白表达与食管鳞癌术后预后的相关性
%A 刘凯
%A 刘艳艳
%A 杨树军
%A 赵燕
%A 郭永军
%A 黄海波
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.01.008
%X 摘要 目的 探讨食管鳞癌患者中酸性富含半胱氨酸分泌型蛋白（SPARC）表达与术后临床特征及预后的相关性。方法 随机选择在郑州大学附属肿瘤医院行手术治疗的初诊食管鳞癌患者89例，收集肿瘤标本和癌旁正常组织，应用免疫组织化学法检测SPARC蛋白的表达，统计分析其与患者临床特征和预后的相关性。结果 食管鳞癌组织SPARC蛋白阳性表达率显著高于癌旁组织（65.17% vs.8.00%, P=0.000），SPARC蛋白优势定位于肿瘤细胞间质中。SPARC蛋白表达与术后淋巴结转移呈负相关（OR=0.369, P=0.038），与病理大体形态、肿瘤分化程度和其他临床特征无关。食管鳞癌患者术后生存与SPARC蛋白表达无关（HR=0.80, P=0.691），而与肿瘤部位（HR=0.34, P=0.037）、分化程度（HR=4.12, P=0.000）和分期（HR=6.36, P=0.017）有关。结论 SPARC蛋白在食管鳞癌间质中高表达，与淋巴结转移负相关，与食管鳞癌术后生存无关
%K Partial Versus Radical Nephrectomy
%K Expression and Clinical Significance of Stem Cells Gene Lgr5 in Esophageal Squamous Cell Carcinoma Tissues
%K Prognostic Value of Circulating Tumor Cells for Metastatic Prostate Cancer: A Metaanalysis
%K Correlation of CD68+ Tumor-associated Macrophages Number with Ki-67 Expression and Prognosis of Patients with Primary Hepatocellular Carcinoma
%K Relationship of Macrophage Migration Inhibitory Factor Expression with Clinicopathologic Features and Prognosis of Cardiac Carcinoma Patients
%K Advance of Prognostic Markers of Cervical Cancer
%K Metaplastic Carcinoma of Breast with Mesenchymal Differentiation: 28 Cases Report
%K Effect of GANT61 on Apoptosis of Esophageal Squamous Carcinoma Cells and Its Mechanism
%K Predictive Value of C-reactive Protein/Albumin Ratio on Prognosis of Patients with Primary Hepatocellular Carcinoma
%K Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer
%K Expression and Clinical Significance of Artemin Protein in Triple-negative and Nontriple-negative Breast Cancer Tissues
%U http://www.zlfzyj.com/CN/abstract/abstract8678.shtml