%0 Journal Article
%T FGF/FGFR信号通路在肺鳞癌靶向治疗中的研究进展
%A 孙震宇
%A 王明
%A 黄礼年
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.07.019
%X 摘要 肺癌是目前世界上发病率和死亡率最高的恶性肿瘤之一。肺鳞癌是仅次于肺腺癌的非小细胞肺癌（NSCLC）最常见的组织学类型，与肺腺癌相比，肺鳞癌的靶向治疗进展明显滞后。FGF/FGFR信号通路的异常改变与很多肿瘤有关，特别是肺鳞癌。FGFR基因扩增、体错义突变、染色体异位是诱导该通路改变的常见机制，故该通路可能是靶向治疗的新方向。本文将对在NSCLC中，特别是肺鳞癌，FGFR的改变以及相关的抑制剂作一综述
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%U http://www.zlfzyj.com/CN/abstract/abstract8804.shtml