%0 Journal Article
%T 重离子辐照对人舌鳞癌CAL27细胞的生物学效应及其分子机制
%A 冯正虎
%A 刘娅丽
%A 杨兰
%A 王志强
%A 王若宇
%A 马丽娟
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1673
%X 摘要 目的 研究重离子12C6+离子辐照对人舌鳞癌CAL27细胞的生物学效应以及分子机制。方法 应用不同剂量重离子束（12C6+）对体外培养的人舌癌CAL27细胞进行辐照，采用MTT、Transwell、流式细胞术、划痕实验、克隆实验观察重离子束（12C6+）对CAL27细胞迁移和侵袭、凋亡和周期的影响，Western blot法观察重离子束（12C6+）对CAL27细胞增殖的影响。结果 （1）重离子辐照对CAL27细胞的增殖抑制作用与剂量-时间成正相关；（2）和空白对照组比较，在相同时间点，不同剂量的重离子束（12C6+）对细胞中P53、P65和VEGF的表达影响明显，随着重离子束（12C6+）辐照剂量增大，细胞中P53、P65和VEGF的表达明显降低（P<0.05）。结论 重离子辐照能抑制CAL27细胞的增殖，且具有剂量和时间效应
%K 重离子
%K 舌鳞状细胞癌
%K P53
%K P65
%K VEGF
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%U http://www.zlfzyj.com/CN/abstract/abstract9203.shtml