%0 Journal Article
%T 粘合连接相关蛋白1在脑胶质瘤中的研究现状及进展
%A 叶敏华
%A 祝新根
%A 范阳华
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.09.013
%X 摘要 粘合连接相关蛋白1（adherens junction associated protein-1，AJAP1），也称为SHREW1，最初发现是在上皮细胞粘合连接有关的一种新奇的跨膜蛋白，位于染色体1p36.32区域。大量的人类癌症病例研究证明，1p36是一个突变热点，在肿瘤发生过程中，肿瘤抑制功能的丧失与1p36区域有关。脑胶质瘤是中枢神经系统最常见的原发性肿瘤，研究显示AJAP1缺失与脑胶质瘤进展有重要关系。在胶质瘤中，AJAP1能够与β-连环蛋白（β-catenin）结合，易位至细胞核内，调节基因转录，影响细胞周期、凋亡及改变细胞骨架结构和细胞极性，抑制细胞的运动及迁移。AJAP1可能是胶质瘤重要的抑制相关靶点，与胶质瘤的发生发展、增殖、凋亡、侵袭及迁移及预后密切相关，但其机制尚未明确。本文就胶质瘤中AJAP1的研究现状及进展进行综述
%K A Clinicopathological Analysis of Seven Cases
%K Effect of HSP70 and iNOS in Process of Hyperthermia Reducing Glioma Invasion
%K Role of Aquaporin-4 in Migration of Human Astrocytoma
%K Effects of Vascular Endothelial Cells on Invasion of Glioma Cells via Notch Signal Pathway
%K MicroRNA-184 Expression in Glioma Tissues and Its Prognosis Value
%K Clinical Analysis of Temozolomide Combined with Radiotherapy on High-grade Glioma
%K Role of IL-1RAP in Gliomas Cells and Its Relationship with STAT3
%K Acute Haematological Toxicity for Patients Treated with Craniospinal Irradiation Helical Tomotherapy Versus Conventional Radiotherapy
%K ERK2 Expression in Human Glioma Tissues and Its Clinical Significance
%U http://www.zlfzyj.com/CN/abstract/abstract8591.shtml