%0 Journal Article
%T ⅡB~Ⅲ期食管癌根治术后预防性放疗疗效分析
%A 宋春洋
%A 李曙光
%A 李腾
%A 祝淑钗
%A 许金蕊
%A 赵彦
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1207
%X 摘要 目的 探讨术后预防性放疗对ⅡB、Ⅲ期胸段食管癌根治术患者生存的影响。方法 收集2007—2010年本院行食管胸段鳞癌根治术患者336例，其中ⅡB期65例、Ⅲ期271例；术后未行放疗组（S）220例，术后放疗组（S+R）116例；放疗中位剂量50 Gy。采用Kaplan-Meier法计算生存率及局控率；Log rank法检验行单因素预后分析。结果 随访率为98.2%，全组患者5年生存率及5年无进展生存率分别为29.3%和25.6%；中位生存时间及中位无进展生存时间分别为26.7月和17.4月。ⅡB期患者S组与S+R组5年生存率分别为30.1%与48.6%，差异无统计学意义（χ 2=2.279, P=0.131）；Ⅲ期患者S组与S+R组5年生存率分别为24.9%与32.8%，差异有统计学意义（χ 2=5.865, P=0.015）；术后病理淋巴结阳性患者S组与S+R组5年生存率分别为25.9%与35.8%，差异有统计学意义（χ 2=7.663, P=0.006）；全组患者S组与S+R组的中位局控时间分别为10.6和16.3月，差异有统计学意义（χ 2=6.043, P=0.014）。结论 食管癌根治术后预防性放疗可明显降低局部复发并使Ⅲ期及术后病理淋巴结阳性的患者生存获益
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%U http://www.zlfzyj.com/CN/abstract/abstract9176.shtml