%0 Journal Article
%T 支持向量机预测食管鳞癌患者术后生存期
%A 刘瑞敏
%A 张天
%A 晁玮霞
%A 朱晗
%A 王广超
%A 王明
%A 谷娟
%A 贺红梅
%A 赵云岗
%A 韩大正
%A 马瑾
%A 马远方
%A 魏书堂
%A 齐义军
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.08.004
%X 摘要 目的 应用支持向量机（support vector machine, SVM）建立食管鳞状细胞癌（esophageal squamous cell carcinoma, ESCC）术后生存期预测模型并评估该模型判断ESCC生存期的效能。方法 随访168例接受根治性手术治疗的ESCC患者，分析ESCC临床病理特征和14-3-3σ、热休克蛋白gp96、巨噬细胞移动抑制因子（migrationinhibitory factor, MIF）等3个蛋白的表达规律与ESCC生存期的相关性；应用Matlab软件进行SVM运算，对训练组128例ESCC患者建立最优预后分类模型ESCC-SVM，并用测试组40例患者验证分类效率，ROC曲线分析ESCC-SVM及其他预后相关因子对高低死亡风险ESCC的识别能力。结果 ESCC-SVM由性别、T分期、组织学分级、淋巴结转移、TNM分期、14-3-3σ和gp96等7个最优属性组成，该模型区分训练组和测试组ESCC五年整体生存率的最大AUC分别为0.96、0.86、准确率分别为97.7%、90.0%，明显优于目前临床应用的TNM分期（准确率分别为62.5%、67.5%）及其他各临床病理属性。Cox多因素比例风险回归模型分析发现年龄、T分期、gp96和ESCC-SVM是影响ESCC术后生存期的独立因素。ESCC-SVM与性别、T分期、组织学分级、淋巴结转移、TNM分期和14-3-3σ均显著相关。结论 本研究建立的ESCC-SVM为预后评估、临床治疗方案选择及个体化治疗提供了理论依据
%K 食管鳞状细胞癌
%K 支持向量机
%K 预后
%K 14-3-3&sigma
%K 热休克蛋白gp96
%K 巨噬细胞移动抑制因子
%K Clinical Analysis of Radiotherapy Combined with Cisplatin-based Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma
%K Relationship Between NF-κB and Epithelial-to-mesenchymal Transition of Radiationinduced Human Esophageal Carcinoma Cells
%K Effect of Gene Silencing of RNF2 on Radiosensitivity of Esophageal Carcinoma Cells
%K Expression and Clinical Significance of Stem Cells Gene Lgr5 in Esophageal Squamous Cell Carcinoma Tissues
%K Department of Thoracic Surgery
%K Zhejiang Cancer Hospital
%K Hangzhou 310022
%K China
%K Effects on Cell Proliferation
%K Invasion and Migration of Esophageal Adenocarcinoma by Inhibition of Notch and PI3K /Akt Pathway
%K Epidemiologic Investigation on Mortality Due to Esophagus Cancer in Residents in Xiamen
%K 2005-2014
%K Effect of GANT61 on Apoptosis of Esophageal Squamous Carcinoma Cells and Its Mechanism
%K Prognosis Factors for Patients with Stage pT3N0M0 Thoracic Esophageal Squamous Cell Carcinoma after Radical Resection
%K Expression of EZH2 and H3K27me3 in Esophageal Squamous Cell Carcinoma and Their Significance
%K Expression of DMRT2 in Esophageal Squamous Cell Carcinoma Tissues and Related Clinical Significance
%K Relationship of Secreted Protein Acidic and Rich in Cysteine Protein Expression with Prognosis of Postoperative Patients with Esophageal Squamous Cell Carcinoma
%K Metastasis?associated Lung Adenocarcinoma Transcript1(MALAT1) Expression in Middle Thoracic Esophageal Squamous Cell Cancer Tissues and Its Relationship with Prognosis
%K Relationship Between Lymphocyte Nadir and Radiotherapy Efficacy or Prognosis of Patients with Esophageal Carcinoma
%K Comparison of 6th and 7th Editions of AJCC/UICC TNM Staging for Esophageal Cancer#br# Patients Received Radiotherapy
%U http://www.zlfzyj.com/CN/abstract/abstract8557.shtml