%0 Journal Article
%T Piwi-interacting RNA在肿瘤中的研究进展
%A 丁梦婷
%A 张蒙
%A 蔡志明
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.09.019
%X 摘要 piRNA（Piwi-interacting RNA）是一类长度为26~31 nt的新型小非编码RNA，可与PIWI蛋白结合从而调控转录基因沉默过程、修饰异染色质和维持生殖系和干细胞功能等。近年来，研究发现piRNA在多种癌组织中表达异常，与肿瘤的发生及扩散、疾病的预后等密切相关，有望成为肿瘤临床诊断和治疗的新靶点。本文旨在浅析piRNA在肿瘤中的作用机制，为临床诊疗提供新思路
%K piRNA
%K PIWI蛋白家族
%K 肿瘤
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%U http://www.zlfzyj.com/CN/abstract/abstract8842.shtml