%0 Journal Article
%T T淋巴细胞免疫球蛋白黏蛋白-3在肿瘤免疫中的研究进展
%A 浦飞飞
%A 邵增务
%J 肿瘤防治研究
%D 2017
%R 10.3971/j.issn.1000-8578.2017.17.0233
%X 摘要 Malignant tumor incidence increases year by year, harming human health seriously. Current treatments include radiotherapy, chemotherapy and molecular targeted therapy. T cell-mediated immune cells play a key role in the body’s anti-tumor effect. In the process of immune response, the participation of coordinated stimulus signals is required to activate T cells, and these signals need “immune checkpoints” to be regulated. TIM-3, as a negative regulatory molecule, expresses selectively on activated Thl cell surface and plays an important regulatory role in the development of a variety of tumors. Therefore, we review the research advances of TIM-3 in tumor immunology through TIM-3 structure, ligands, expression in tumor, mechanism of immune regulation and immunotherapy
%K A Specialty that Goes Beyond Managing Cardiovascular Toxicity
%K Diagnosis and Treatment of Hepatitis C Virus Reactivation After Anti-cancer Therapies
%K SLC9A3R1 Overexpression Inhibits Proliferation of Breast Cancer Cell Line MDAMB-231
%K Relationship of CD44＋/CD24－/low with Responsiveness of Breast Cancer to Anthracycline-based Chemotherapy
%U http://www.zlfzyj.com/CN/abstract/abstract9054.shtml