%0 Journal Article
%T 乳腺癌组织中PDK4的表达及其与预后的关系
%A 刘佳
%A 吴娟子
%A 吴鹏
%A 孙书娟
%A 赵美松
%A 韩迎燕
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0737
%X 摘要 目的 探讨影响乳腺癌组织中PDK4的表达与预后的相关性。方法 PubMed数据库The Gene Expression Omnibus（GEO, http://www.ncbi.nlm.nih.gov/geo/）分析PDK4在正常乳腺及乳腺癌组织中的表达水平。使用The Kaplan–Meier plotter（www.kmplot.com）分析工具评估PDK4表达水平与乳腺癌临床预后的相关性。TGF-β细胞因子处理MCF-7细胞系，Real-time PCR技术检测经处理后MCF-7细胞系中PDK4 mRNA表达水平。siRNA干扰技术降低细胞内PDK4的表达水平，Transwell检测MCF-7细胞的侵袭能力。结果 PDK4在乳腺癌组织中的表达水平低于正常乳腺组织，并且PDK4低表达与乳腺癌预后差呈正相关；在乳腺癌细胞系中，TGF-β降低PDK4 mRNA表达水平，且PDK4的低表达增强了MCF-7细胞的侵袭能力。结论 PDK4低表达是乳腺癌预后差的一个重要指标
%K A Meta-analysis
%K Value of 18F-FDG PET/CT in Evaluating Chemotherapeutic Effect of Diffuse Large B Cell Lymphoma Patients with Different CD5 Expression
%K Advances in Prognostic Value of Peripheral Blood Inflammatory Indexes in Non-small Cell Lung Cancer
%K Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer
%K Immunoprecipitation-mass Spectrometry Reveals New Functions of RCC2 in Breast Cancer Cell Line MDA-MB-468
%K Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients
%K Cholesterol: A Predictor of Risk and Prognosis of Breast Cancer
%K Predictive Value of Preoperative Hematologic Inflammatory Markers in Prognostic of Glioma Patients
%U http://www.zlfzyj.com/CN/abstract/abstract9105.shtml