%0 Journal Article
%T 外周血中性粒细胞及血小板与淋巴细胞的比值与局部晚期鼻咽癌预后及疗效的相关性
%A 吴伟莉
%A 唐红
%A 张芒
%A 李媛媛
%A 杨春李
%A 罗秀玲
%A 金风
%A 陈潇潇
%A 龙金华
%A 龚修云
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.0578
%X 摘要 目的 探讨中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio, NLR）以及血小板与淋巴细胞比值（platelet-lymphocyte ratio, PLR）对局部晚期鼻咽癌患者临床预后及疗效的预测价值。方法 收集2015年7月—2016年12月贵州省肿瘤医院一项随机前瞻性临床试验的局部晚期鼻咽癌患者的临床资料。患者均行2周期TPF诱导化疗及顺铂同步放化疗。研究治疗前NLR、PLR与患者治疗疗效的关系。并探讨时辰组及常规组间疗效的差异。结果 Ⅳa/b期患者NLR、PLR均值较Ⅲ期患者高（P=0.010）；低PLR组治疗后转移淋巴结即刻疗效较高PLR组好（P=0.029），放疗结束3月后原发灶疗效及总体疗效较高PLR组好（P=0.012, P=0.027）；高、低NLR及PLR组中常规组及时辰组的治疗后即刻疗效及放疗结束后3月疗效差异无统计学意义（P>0.05）。结论 NLR和PLR均与鼻咽癌临床分期有关，肿瘤分期越晚，NLR和PLR值越高。NLR对患者的近期疗效预测价值欠佳，PLR可能是局部晚期鼻咽癌患者近期疗效的预测指标，高PLR可能预示较差的近期疗效
%K A Meta-analysis
%K Value of 18F-FDG PET/CT in Evaluating Chemotherapeutic Effect of Diffuse Large B Cell Lymphoma Patients with Different CD5 Expression
%K Advances in Prognostic Value of Peripheral Blood Inflammatory Indexes in Non-small Cell Lung Cancer
%K Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients
%K Cholesterol: A Predictor of Risk and Prognosis of Breast Cancer
%K Progress on Comprehensive Treatment of Nasopharyngeal Cancer
%K Predictive Value of Preoperative Hematologic Inflammatory Markers in Prognostic of Glioma Patients
%K Clinical Treatment and Prognosis of 101 Patients with Small Cell Neuroendocrine Carcinoma of Cervix
%K Effect of Marital Status on Survival of Lung Cancer Patients Investigated Based on SEER Database
%K Clinical Characteristics and Prognosis of Primary Thyroid Lymphoma Patients
%U http://www.zlfzyj.com/CN/abstract/abstract9313.shtml