%0 Journal Article
%T miR-130b调控RAB34的表达在胰腺癌发生发展中的作用
%A 丁锋
%A 何峰
%A 曹忠厚
%A 程方雄
%A 闵小春
%A 陈曦
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0960
%X 摘要 目的 探讨miR-130b调控Ras相关蛋白34（Ras-related proteins in brain 34, RAB34）在胰腺癌中的表达。方法 收集22例胰腺癌及其癌旁组织标本，采用免疫组织化学、Western blot和qRT-PCR法检测RAB34的表达；qRT-PCR法检测miR-130b表达；细胞转染法检测miR-130b调控RAB34表达，双荧光素酶报告基因检测系统验证miR-130b结合RAB34的3’UTR的靶位点。结果 与癌旁组织对比，RAB34在胰腺癌组织中显著高表达，且miR-130b显著低表达；转染miR-130b mimics可抑制RAB34的表达；RAB34是miR-130b作用的靶基因。结论 RAB34是胰腺癌的分子标志物，miR-130b可调控其表达
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%U http://www.zlfzyj.com/CN/abstract/abstract9120.shtml