%0 Journal Article
%T β1,3-乙酰葡萄糖胺转移酶3在非小细胞肺癌中的表达及其临床意义
%A 严宝国
%A 向正凯
%A 李斌峰
%A 熊飞
%A 王华斌
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1638
%X 摘要 目的 探讨β1,3-乙酰葡萄糖胺转移酶3（β1,3-N-acetylglucosaminyltransferase-3, B3GNT3）在非小细胞肺癌（non-small cell lung cancer, NSCLC）组织中的表达及其临床意义。方法 通过在线TCGA数据库分析B3GNT3基因的表达；Western blot法及免疫组织化学法检测60例NSCLC组织及22例正常肺组织中B3GNT3蛋白的表达情况，分析B3GNT3蛋白表达与NSCLC患者临床病理特征及预后之间的关系。结果 NSCLC患者组织中B3GNT3基因和蛋白表达明显高于正常肺组织，差异有统计学意义（P<0.01）。B3GNT3蛋白表达与NSCLC患者的年龄、性别、吸烟情况、种族、TNM分期均无明显关系（P>0.05）。B3GNT3高表达组患者生存期明显短于B3GNT3低表达组患者（P<0.05）。结论 B3GNT3蛋白在NSCLC组织中高表达，且其表达高低与NSCLC患者预后有关
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%U http://www.zlfzyj.com/CN/abstract/abstract9212.shtml