%0 Journal Article %T 不同原发部位结肠癌的临床病理及预后分析 %A 徐慧婷 %A 徐洪丽 %A 梁新军 %A 肖志华 %A 胡俊杰 %A 魏少忠 %J 肿瘤防治研究 %D 2018 %R 10.3971/j.issn.1000-8578.2018.18.0017 %X 摘要 目的 探讨不同原发部位的结肠癌患者临床病理及预后是否存在差异。方法 回顾性分析1 088例结肠癌患者的临床病理资料,应用Kaplan-Meier法进行生存分析,Log rank法比较生存率差异,肿瘤不同部位对预后影响的多因素分析采用Cox比例风险回归模型。结果 升结肠组患者平均年龄最大(61.1±12.3)岁,女性患者所占比例最高(47%)。升结肠组和横结肠组肿瘤直径(5.9±2.2 cm和5.8±2.4 cm)显著大于降结肠组及乙状结肠组(4.4±1.8 cm和4.6±1.7 cm)(P=0.000)。乙状结肠组Ⅰ期患者所占比例最高(9.9%),约为升结肠组的3倍(3.8%)(P=0.001)。升结肠组和横结肠组肿瘤中黏液分泌、低分化及未分化和脉管瘤栓比例均显著高于降结肠组及乙状结肠组,差异均有统计学意义。升结肠组、横结肠组、降结肠组和乙状结肠组患者5年总生存率分别为71.4%、75.4%、73.5%和79.7%,差异有统计学意义(P=0.000)。经多因素回归分析调整后,与升结肠组患者相比,乙状结肠组死亡风险显著降低(HR=0.68, 95%CI: 0.50~0.91)。按期别分层分析显示乙状结肠癌(HR=0.54,95%CI: 0.32~0.90)在Ⅳ期结肠癌中预后最优。结论 不同原发部位的结肠癌患者临床病理及预后存在差异,Ⅳ期结肠癌中乙状结肠癌预后最佳 %K A Meta-analysis %K Value of 18F-FDG PET/CT in Evaluating Chemotherapeutic Effect of Diffuse Large B Cell Lymphoma Patients with Different CD5 Expression %K Advances in Prognostic Value of Peripheral Blood Inflammatory Indexes in Non-small Cell Lung Cancer %K Effects of MicroRNA-4465 on Apoptosis and Invasion of Colon Cancer Cells %K Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma %K Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients %K Cholesterol: A Predictor of Risk and Prognosis of Breast Cancer %K Effect of Noscapine on Drug Resistance of 5-Fluorouracil-resistant Human Colon Cancer Cell Lines HT-29/5-Fu %K LoVo/5-Fu and SW480/5-Fu %K Regulatory Effect of Astragaloside A on Proliferation and Apoptosis of Human Colon Cancer SW480 Cell Line %U http://www.zlfzyj.com/CN/abstract/abstract9232.shtml