%0 Journal Article
%T 阿比特龙联合泼尼松治疗去势抗拒前列腺癌的临床观察
%A 张华锋
%A 李长岭
%A 许玉霞
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.04.014
%X 摘要 目的 探讨新型雄激素合成抑制剂醋酸阿比特龙（Abriaterone acetate）治疗去势抗拒前列腺癌（castration-resistant prostate cancer，CRPC）的疗效及安全性。方法 经病理证实并符合入选标准的58例去势抗拒前列腺癌患者，中位年龄68岁（61~81岁），接受醋酸阿比特龙治疗，化疗至少2周期后。按实体瘤疗效评价标准（RECIST）美国NCI制定的毒性评价指标（CTC-AE3.0）评价疗效和毒性反应；采用Kaplan-meier法对患者总生存时间（OS）进行分析。结果 5例未完成总评估过程。可评价疗效的53例患者中，总有效率（ORR）18.87%（10例），疾病控制率（DCR）62.26%（33例）；中位OS为（15.0±1.2）月； 28例前列腺特异性抗原（prostate-specific antigen，PSA）下降﹥50%，治疗前后PSA中位数分别为78 ng/ml（18~1 776 ng/ml）和37 ng/ml（9~320 ng/ml），两者比较差异有统计学意义（P﹤0.05） ；化疗不良反应多为Ⅰ~Ⅱ级。结论 阿比特龙联合泼尼松治疗去势抗拒前列腺癌疗效较好，不良反应轻
%K 醋酸阿比特龙
%K 泼尼松
%K 去势抗拒前列腺癌
%K 疗效
%K 安全性
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%U http://www.zlfzyj.com/CN/abstract/abstract8470.shtml