%0 Journal Article
%T 乙肝病毒感染状态及表面抗原/抗体水平与结肠癌分期和预后的关联
%A 刘进生
%A 林鑫
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0683
%X 摘要 目的 观察结肠癌患者乙肝病毒感染状态及表面抗原/抗体水平，分析其与结肠癌分期的关联，从而间接评估结肠癌患者合并乙型肝炎对其预后的影响。方法 收集福建省立医院收治的85例结肠癌患者，采用SPSS16.0统计软件回顾性分析乙肝病毒感染状态对结肠癌浸润深度、区域淋巴结转移和远处转移的影响。结果 乙肝病毒感染状态对结肠癌原发灶浸润深度（T）（P=0.331）和结肠癌区域淋巴结转移（N）的影响差异无统计学意义（P=0.098）。合并乙肝病毒阳性的结肠癌患者其区域淋巴结转移度明显低于乙肝病毒阴性的亚组（8.1% vs. 17.8%），且无区域淋巴结转移的结肠癌患者血清中HbsAb水平较发生淋巴结转移的亚组患者明显升高（240.111 mIU/ml vs. 178.161 mIU/ml）。乙肝病毒感染状态对结肠癌患者发生远处转移（M）以及肝转移的影响差异均具有统计学意义（均P<0.001）。不论是乙肝病毒感染还是乙肝疫苗相关的乙肝病毒阳性患者，肝转移发生率均显著低于乙肝病毒阴性的患者（P=0.039, P<0.001）。 结论 结肠癌合并乙肝病毒表面抗体水平高表达对区域淋巴结转移可能具有潜在的抑制作用。乙肝病毒阳性对结肠癌发生远处转移（尤其对肝转移）呈显著性负相关。乙肝病毒感染状态以及表面抗原/抗体水平显著性影响结肠癌患者的分期及预后
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%U http://www.zlfzyj.com/CN/abstract/abstract9107.shtml