%0 Journal Article
%T 丹参酮ⅡA抑制奥沙利铂诱发周围神经病变大鼠神经生长因子的表达
%A 成薇婷
%A 王珊
%A 胡作为
%A 许凯
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.07.002
%X 摘要 目的 观察丹参酮ⅡA对奥沙利铂诱发周围神经毒性大鼠的神经生长因子的抑制作用。方法 30只健康Wistar大鼠随机分成3组，对照组、模型组、丹参酮防治组。除对照组外，其余各组均予以腹腔注射奥沙利铂（20 mg/kg）造模。防治组在造模前3天至造模后第7天持续给药；并利用神经电生理仪检测大鼠机械性痛阈和冷刺激性疼痛，Western blot检测脊髓背角神经中神经生长因子（nerve growth factor，NGF）的表达。结果 造模后6 h大鼠机械性痛阈较对照组降低，冷刺激缩足时间缩短（P<0.05），并随着观察时间的延长，痛阈值明显下降，在72 h达到最低并一直持续1周；第7天检测各组大鼠脊髓背角神经元中NGF表达情况，模型组较对照组明显降低；应用丹参酮ⅡA干预后，与模型组相比，大鼠机械性痛阈明显回升，对冷刺激耐受时间延长，NGF表达量明显增高（P<0.05）。结论 丹参酮ⅡA可能是通过提高NGF的表达，发挥防治奥沙利铂诱导的周围神经病变的作用
%K 丹参酮ⅡA
%K 奥沙利铂
%K 周围神经毒性
%K 神经生长因子
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%U http://www.zlfzyj.com/CN/abstract/abstract8531.shtml