%0 Journal Article
%T 一氧化氮前体药物与前列腺癌的研究进展
%A 柳建军审校
%A 谭国斌综述
%A 陈合格
%A 陈烈钳
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.02.014
%X 摘要 前列腺癌是男性最常见的肿瘤之一。一氧化氮（nitric oxide, NO）作为生物信使或效应分子在体内发挥重要的生理作用，且其体内水平异常与多种疾病的发生和发展密切相关。因此，一氧化氮前体型药物的研究备受关注。一些NO前体药物已被证实具有良好的抗肿瘤活性，显示出广泛的临床应用潜力和价值。目前，NO前体药物中显示出显著抗肿瘤效应的主要有有机硝酸酯、硝普盐、S-亚硝基硫醇和偶氮二醇烯鎓盐等。一氧化氮前体药可通过靶向释放NO，直接杀伤肿瘤细胞、诱导肿瘤细胞凋亡、增强免疫系统作用、削弱肿瘤细胞增殖及侵袭能力，并抑制其转移，提高肿瘤细胞对放化疗的敏感度，从而发挥抗肿瘤作用。本文就近年来NO前体药物对前列腺癌作用的研究进展作一综述
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%U http://www.zlfzyj.com/CN/abstract/abstract8704.shtml