%0 Journal Article
%T 表观遗传调控剂在乳腺癌治疗中的研究进展
%A 李小雷
%A 王林波
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.05.020
%X 摘要 近年来，随着对不同类型乳腺癌基因表达谱研究的深入，表观遗传调节剂用来调控乳腺癌异常表达基因而应用于临床。初步结果表明，DNA甲基转移酶和组蛋白去乙酰化酶抑制剂对不同类型的乳腺癌（包括耐药性乳腺癌）均有不同的治疗作用。本文从体外实验研究、临床试验方面，分别对将来可能应用于乳腺癌治疗的表观遗传调节剂进行综述
%K 乳腺癌
%K 表观遗传调节剂
%K DNA甲基转移酶
%K 组蛋白去乙酰化酶
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%K Effect of Thyroid Hormone Receptor βΔ on Proliferation and Apoptosis of Rat Breast Cancer Cells SHZ-88
%K Progress on FOXP3 Expression in Breast Cancer Cells
%K Effect of Hormones from Adrenal Gland on Breast Cancer Metastasis in Mice
%K Effect of SAHA on Proliferation and Apoptosis of Breast Cancer Cells MDA-MB-435 and Related Mechanism
%K Analysis E-cad and VEGF Expression in Triple-negative Breast Cancer of Han and Uygur
%K Regulations and Roles of Breast Cancer Stem Cells
%K Prediction of Disease Specific Survival Rates by Genes Associated with Relapse of Breast Cancer
%K Correlation Between Tumor Associated Macrophages and CXCL12 Expression in Different Breast Tissues
%K Effects of NRP-1 Overexpression on Biological Behaviors of Breast Cancer Cell Lines MDA-MB-231 and SK-BR-3
%K Effect of Operation Incision Selection on Success rate of Sentinel Lymph Node Biopsy and Subcutaneous Hydrops in Breast Cancer
%K Expression and Clinical Significance of Artemin Protein in Triple-negative and Nontriple-negative Breast Cancer Tissues
%U http://www.zlfzyj.com/CN/abstract/abstract8758.shtml