%0 Journal Article
%T 每周脂质体紫杉醇或奥沙利铂联合替吉奥方案治疗老年晚期胃癌的疗效及安全性分析
%A 庄志祥
%A 张玉松
%A 朱民高
%A 沈旭东
%A 甘蕾
%A 陈志刚
%A 陈蕾
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.05.017
%X 摘要 目的 比较每周脂质体紫杉醇联合替吉奥与奥沙利铂联合替吉奥一线治疗老年晚期胃癌的疗 效及安全性。方法 将119例老年晚期胃癌患者随机分为两组，A组62例患者采用每周脂质体紫杉醇联 合替吉奥方案，B组57例患者采用奥沙利铂联合替吉奥方案。比较两组患者的近期疗效、无疾病进展 时间（PFS）、总生存时间（OS）、体能状态和不良反应。结果 A组患者的客观缓解率（ORR）、 疾病控制率（DCR）、PFS、OS分别为22.0%、69.5%、6.4月和10.8月，B组分别为25.0%、67.9%、 6.4月和10.4月，两组间差异均无统计学意义（P均>0.05）。B组Ⅰ~Ⅱ级胃肠道反应、Ⅰ~Ⅱ级和Ⅲ~ Ⅳ级外周神经毒性发生率均较A组严重（P均<0.05）。结论 每周脂质体紫杉醇联合替吉奥治疗老年 晚期胃癌的近期疗效与传统的奥沙利铂联合替吉奥相似，但前者患者的耐受性更好，可推荐作为老年 晚期胃癌患者治疗的首要选择
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%U http://www.zlfzyj.com/CN/abstract/abstract8755.shtml