%0 Journal Article
%T TIP方案一线治疗晚期中高危睾丸生殖细胞肿瘤的回顾性分析
%A 周莉
%A 唐碧霞
%A 崔传亮
%A 斯璐
%A 李思明
%A 毛丽丽
%A 王轩
%A 白雪
%A 盛锡楠
%A 连斌
%A 迟志宏
%A 郭军
%A 鄢谢桥
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1417
%X 摘要 目的 回顾性分析紫杉醇、异环磷酰胺联合顺铂（TIP）方案作为一线治疗晚期中高危睾丸生殖细胞肿瘤的疗效和安全性。方法 选取晚期中高危男性睾丸生殖细胞肿瘤患者，一线给予TIP方案进行治疗，评估该方案的客观有效率、2年的无进展生存率（PFS）和总生存率（OS）。结果 共20例患者纳入本研究，平均用药周期为4.25周期，6 例患者获得完全缓解（30%），7例患者获得部分缓解（35%）， 客观有效率65%。中位随访时间25月，3例患者因肿瘤进展死亡。2年的PFS率为72.9%，OS率为89.1%。血液学毒性为最常见的不良反应 （95%），其中3~4级中性粒细胞减少的发生率为30%。结论 TIP方案一线治疗晚期中高危睾丸生殖细胞肿瘤较既往报道提高了患者的PFS率和OS率，不良反应可控，确立为一线方案仍需大样本临床研究
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%U http://www.zlfzyj.com/CN/abstract/abstract9175.shtml