%0 Journal Article
%T 常用血清肿瘤标志物在可手术肺癌患者预后中的价值
%A 张善渊
%A 李少雷
%A 杨跃
%A 雄英
%A 马媛媛
%A 黄淼
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0854
%X 摘要 目的 探讨血清CEA、CA125、CA199、NSE、CYFRA21-1和SCC-Ag水平在评估非小细胞肺癌根治手术后的预后价值，以期合理选择术前的检验指标。方法 收集1 851例行肺癌根治手术的患者术前血清肿瘤标志物的检验值、临床病理和随访信息，进行差异及生存分析。结果 CEA、CA125、CA199、CYFRA21-1和SCC-Ag的阳性率在不同病理分期中差异有统计学意义（P<0.001），Ⅱ和Ⅲ期的患者阳性率明显高于Ⅰ期患者，而NSE差异无统计学意义（P=0.743）。CEA、CA125、CA199、CYFRA21-1阴性组患者的生存率显著高于阳性组（P<0.05）。NSE阴性的患者远期生存率劣于阳性组患者（P=0.033）。SCC-Ag阳性与阴性患者的远期生存率差异无统计学意义（P=0.072）。Cox回归比例风险模型分析发现CEA（HR=1.572, 95%CI: 1.117~2.214, P=0.010）、CA125（HR=2.464, 95%CI:1.610~3.772, P<0.001）和CYFRA21-1（HR=1.445, 95%CI: 1.044~2.000, P=0.027）是评价非小细胞肺癌手术预后的独立危险因素。结论 CEA、CA125和CYFRA21-1在评价非小细胞肺癌手术预后方面有良好的应用价值，而CA199、NSE和SCC-Ag等指标价值有限
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%U http://www.zlfzyj.com/CN/abstract/abstract9094.shtml