%0 Journal Article
%T 少突胶质细胞瘤中染色体1p/19q联合缺失与MGMT基因启动子甲基化的相关性
%A 宋锦宁
%A 宫惠琳
%A 张冠军
%A 张娇娇
%A 梁华
%A 汪园园
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1543
%X 摘要 目的 研究少突胶质细胞瘤染色体1p/19q联合缺失与MGMT基因启动子甲基化的相关性。方法 选取少突胶质细胞瘤35例、间变型少突胶质细胞瘤32例标本作为实验组，星形细胞瘤20例及瘤旁正常脑组织标本20例作为对照组，荧光原位杂交方法检测染色体1p/19q联合缺失情况，巢式甲基化特异性PCR技术检测MGMT基因启动子甲基化情况。结果 少突胶质细胞瘤和间变型少突胶质细胞瘤1p/19q联合缺失率分别为85.71%、75.00%，均显著高于星形细胞瘤及正常脑组织（P<0.05）；少突胶质细胞瘤、间变型少突胶质细胞瘤、星形细胞瘤的MGMT基因启动子甲基化率均显著高于正常脑组织（P<0.05），但三者组间比较差异无统计学意义（P>0.05）；少突胶质细胞瘤1p/19q联合缺失与MGMT基因启动子甲基化呈正相关性，并且均与患者3年生存率相关（P<0.05）。结论 少突胶质细胞瘤中1p/19q联合缺失与MGMT基因启动子甲基化状态密切相关，联合检测有助于提高临床病理诊断的精确性，更好地评估预后
%K 胶质瘤少突胶质细胞瘤
%K 1p/19q联合缺失
%K MGMT
%K 甲基化
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%U http://www.zlfzyj.com/CN/abstract/abstract9208.shtml