%0 Journal Article
%T 术前血小板和淋巴细胞比值对胃间质瘤患者预后的预测价值
%A 张献
%A 李威
%A 胡根
%A 邵国益
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1428
%X 摘要 目的 探讨术前血小板/淋巴细胞比值（PLR）在胃间质瘤（GST）患者预后评估中的作用。方法 回顾性分析了92例GST患者的临床病例资料。收集所有GST患者术前3天血常规PLR数值及其病理切片中免疫组织化学检测结果。根据术前外周血PLR分为低PLR组（PLR<130, 38例）和高PLR组（PLR≥130, 54例），比较两组GST患者的生存情况，分析临床病理因素与术后无瘤生存率、总生存率之间的关系。结果 术前PLR与GST临床病理特征中的核分裂相有关（χ2=5.95, P=0.015）。术前高PLR组患者的无瘤生存率明显低于术前低PLR组，差异有统计学意义（χ2=6.17, P=0.018）。单因素分析结果显示，术前PLR、术后是否接受伊马替尼治疗、美国国立卫生研究院（NIH）的肿瘤恶性潜能分级、肿瘤大小、肿瘤核分裂相与GST的术后无瘤生存率相关（P<0.05）。多因素分析结果发现，术前PLR是GST术后无瘤生存率的独立预后因素（P<0.05）。结论 术前PLR可作为GST的独立预后因素。术前高PLR可能提示GST患者预后不良
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%U http://www.zlfzyj.com/CN/abstract/abstract9192.shtml