%0 Journal Article
%T 不同放化疗治疗模式对肺癌患者放射性肺炎发生的影响
%A 刘锐锋
%A 张秋宁
%A 王小虎
%A 罗宏涛
%A 董玉梅
%A 魏世鸿
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.18.0065
%X 摘要 目的 比较肺癌放疗患者不同放化疗治疗模式下2级以上放射性肺炎（RP）发生的差异，以及临床治疗特征对RP发生的影响。方法 回顾性分析自2014年1月至2016年1月在我院行放化疗综合治疗的肺癌患者136例，按期随访并复查肺功能、胸部CT，按RTOG急性放射肺炎评价标准对肺损伤分级进行评价，分析临床特征及治疗模式对RP发生的影响。结果 ≥2级RP 36例，发生率为26.5%。临床特征方面，粉尘接触史和病理类型与RP发生有一定相关性（P=0.048, 0.047），其余指标方面差异均无统计学意义。治疗模式方面，序贯放化疗与同步放化疗比较，在总RP发生、2级和3级RP发生率方面差异均无统计学意义，而≥4级RP发生率两组比较差异有统计学意义（6.7% vs. 0, P=0.05）。不同化疗方案之间比较在≥2级RP发生方面差异无统计学意义。RP严重程度与总化疗周期数及诱导化疗周期数呈显著正相关（P=0.000）。结论 粉尘接触史和病理类型是临床特征方面增加RP发生的独立因素。不同治疗模式对RP的发生有一定的影响，其中与患者化疗周期数密切相关，特别是总化疗周期或诱导化疗周期
%K A Retrospective Study
%K Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy
%K Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy
%K Effect of Selective Increase of Single Dose of PTV on Prognosis of Patients with Esophageal Cancer
%K Evaluation of 192Ir-Based Hypofractionated Stereotactic Ablative Brachytherapy as A Neoadjuvant Treatment for Operable Peripheral Non-small Cell Lung Cancer
%K Research Progress of Radiation-indnced Heart Disease
%K Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis
%K Prophylactic Radiotherapy for Procedure Tract Metastases in Malignant Pleural Mesothelioma: A Meta-analysis
%K Comparison of Efficiency and Safety Between Radiofrequency Ablation and Stereotactic Body Radiotherapy on Primary Small Hepatocellular Carcinoma
%K Carbon Ion Radiotherapies for Adenoid Cystic Carcinoma
%K Patterns of Failure After Radical Surgery on Patients with StageⅡ/Ⅲ Thoracic Esophageal Squamous Cell Carcinoma
%K Relationship Between NF-κB and Epithelial-to-mesenchymal Transition of Radiationinduced Human Esophageal Carcinoma Cells
%K Effect of Intensity Modulated Radiotherapy Combined with Hormonal Therapy on Fatigue in Patients with Locally Advanced Prostate Cancer
%K Prognosis of Clinical Stage ⅢA(N2) Non-small Cell Lung Cancer Patients Received Radiotherapy
%U http://www.zlfzyj.com/CN/abstract/abstract9170.shtml