%0 Journal Article %T 抗肿瘤药物相关性心血管疾病的发生机制研究进展 %A 申维玺 %A 谭文勇 %J 肿瘤防治研究 %D 2018 %R 10.3971/j.issn.1000-8578.2018.18.0422 %X 摘要 在肿瘤患者的死亡原因中,恶性肿瘤本身导致的死亡为首位原因,其次为抗肿瘤治疗相关性心脏疾病。肿瘤和心血管疾病作为最主要的慢性非传染性疾病,抗肿瘤药物治疗可能导致多种心血管事件,并日益受到关注。抗肿瘤药物包括化疗药物、分子靶向药物和免疫检查点抑制剂,多数可引起不同程度的心血管疾病,称为抗肿瘤药物治疗相关性心脏病。本文重点讨论各种抗肿瘤药物引发心血管疾病的发病机制,为肿瘤研究和临床实践提供参考 %K Advances in Immunotherapy for Malignant Tumors %K Cardiotoxicity and Mechanisms of Immune Checkpoint Inhibitors %K Effects of Whole-brain Radiotherapy Combined with Targeted Therapy on Improving Survival of HER2-positive Breast Cancer Patients with Brain Metastases %K Research Progress of CD47-SIRPα Signaling Axis as An Innate Immune Checkpoint in Cancer %K Effect of Antiacid Drugs on Absorption of Small Molecular Targeted Drugs %K Progress of Molecular Imaging-guided Tumor Immunotherapy %K Novel Findings on Activation of PD1/PD-L1 that Contributes to Cancer Development and Metastasis %U http://www.zlfzyj.com/CN/abstract/abstract9265.shtml