%0 Journal Article
%T 雌激素受体GPER在乳腺癌中的研究现状
%A 余腾骅
%A 涂刚
%A 赵晨晖
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.12.017
%X 摘要 G蛋白偶联雌激素受体（G protein-coupled estrogen receptor, GPER, 也称GPR30）在多种类型细胞中均可介导雌激素信号，其在乳腺癌、子宫内膜癌等激素敏感性肿瘤细胞中的作用尤为明显。雌激素及抗雌激素药物通过激活GPER促进下游信号通路的活化及靶基因的表达进而参与乳腺癌细胞的增殖、迁移、侵袭及他莫昔芬耐药等恶性生物学行为。目前发现表皮生长因子受体（epidermal growth factor receptor, EGFR）的转活是GPER引发下游生物学效应的关键靶点。此外，GPER还被认为是预测三阴乳腺癌患者预后的潜在生物学标志物之一，对GPER的深入研究可能为乳腺癌患者的综合性评估和临床治疗打开更广阔的前景
%K G蛋白偶联雌激素受体（GPER/GPR30）
%K 雌激素
%K 他莫昔芬耐药
%K 三阴性乳腺癌
%K Effect of Neoadjuvant Chemotherapy Cycles on Pathologic Complete Response Rate Under Different Estrogen Receptor Status of Breast Cancer
%K Analysis E-cad and VEGF Expression in Triple-negative Breast Cancer of Han and Uygur
%K Role of IL-6 in Progress of Estrogen Promoting Lung Adenocarcinoma in Mice and Its Mechanism
%K Correlation Between Epithelial-mesenchymal Transition and Sensitivity to EGFR Targeted Monoclonal Antibody in Triple Negative Breast Cancer Cells
%K Progress of Relationship Between Estrogen Receptor (ER)-α36 and Breast Cancer
%K Establishment of DDP Resistant Variant of Triple Negative Breast Cancer Cell Line MDA-MB-231/DDP and Its Appraisal
%K Clinical Efficacy and Toxicities of Oxaliplatin plus S-1(SOX) and Gemcitabine plus Cisplatin (GP) Regimens on Advanced Triple-negative Breast Cancer Patients
%K Valuation of SUVmax
%K Ki-67
%K p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients
%K Influences of miR-206 on Sensitivity of Estrogen Receptor-α Positive Breast Cancer Cells MCF-7 to Tamoxifen
%K Beclin 1 Protein Enhances Sensitivity of Triple-negative Breast Cancer Cell Line BT-549 to 5-Fu by Promoting Cell Apoptosis
%K Molecular Classification of Triple Negative Breast Cancer and Its Applications
%K Molecular Stratification and Targeted Therapy for Triple-negative Breast Cancer
%K Clinicopathologic Features of Triple Negative Breast Cancer and Their Correlation with Drug-sensitive Protein
%K Retrospective Analysis of Capecitabine in Routine Treatment of Advanced Triple#br# Negative-breast Carcinoma
%K Inhibitory Effect of Celecoxib on Triple-negative Breast Cancer Stem Cells in vitro
%U http://www.zlfzyj.com/CN/abstract/abstract8665.shtml