%0 Journal Article
%T 胃黏膜瘤变过程中差异蛋白的表达
%A 关晓英
%A 王芙蓉
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1439
%X 摘要 目的 探讨胃癌发生发展的不同阶段（正常胃黏膜组织、反应性增生、低级别上皮内瘤变、高级别上皮内瘤变及黏膜内腺癌）差异蛋白的表达。方法 以胃窦部肠型胃癌为研究对象，选取正常、反应性增生、低/高级别上皮内瘤变、黏膜内癌5组各30例共150例组织标本，用非标记蛋白质组学（labelfree）联合液性色谱质谱（LC-MC/MC）筛选差异蛋白，并评估差异蛋白潜在的生物学功能。结果 筛选出了8个差异蛋白，和正常黏膜相比，在低级别上皮内瘤变—高级别上皮内瘤变及黏膜内癌的发展过程中，LAMN1、ERGIC1、UQCRFS1、UQCRH和CISD1这5个蛋白质的表达量逐渐降低，表达量逐渐升高的蛋白质有HMGB1、DNA-PKcs和14-3-3。结论 在胃癌发生发展的不同阶段，蛋白质的表达存在明显的差异，这些差异蛋白具有成为胃癌早期诊断及靶向分子治疗标志物的潜能
%K 胃癌
%K 异型增生
%K 分子标志物
%K 蛋白质组学
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%K Effect of Da Vinci Robot Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones of Gastric Cancer Patients
%K Effect of ANLN Gene Silencing on Invasion
%K Migration
%K Proliferation and Apoptosis of Gastric Cancer Cells
%K Related Factors and Risk Model Prediction of Pneumonia After ESD in Patients with Early Gastric Cancer
%K Effect of FBXL20 on Proliferation
%K Migration and Invasion of Gastric Cancer Cells
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%K Expression of CRT and CD47 in Gastric Carcinoma and Their Significance
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%K Effect of Yes-associated Protein Knockdown on Apoptosis of Gastric Cancer BGC823 Cells Through Wnt/β-catenin Signaling Pathway
%K Short-term Efficacy and Safety of Total Laparoscopic and Laparoscopic-assisted Radical Gastrectomy on Distal Gastric Cancer
%K Annexin A5 Knockdown Prompts Proliferation of Gastric Cancer MKN-45 Cells
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%U http://www.zlfzyj.com/CN/abstract/abstract9213.shtml