%0 Journal Article
%T 核仁小分子RNAs与癌症的研究进展
%A 丁翠玲
%A 王文
%A 王鹏
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.01.021
%X 摘要 核仁小分子RNAs (small nucleolar RNAs, snoRNAs) 是一类小分子非编码RNA，其广泛分布于真核生物的细胞核核仁中。近年来，越来越多的研究证明snoRNAs的失调与癌症相关。snoRNAs可能作为抑制基因或原癌基因参与到癌症发生与发展的过程中。并且，snoRNAs相关的基因印记、人端粒末端转移酶以及核糖体病变也被发现与癌症的发生有关。另外，snoRNAs在癌症的诊断与治疗中具有潜在的应用。本文简要总结了snoRNAs的新功能以及snoRNAs在癌症诊断与治疗中潜在应用的研究进展
%K 核仁小分子RNAs
%K 癌症
%K 癌症诊断与治疗
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%U http://www.zlfzyj.com/CN/abstract/abstract8403.shtml