%0 Journal Article
%T 芦荟苷对食管癌细胞系KESY70增殖、凋亡和侵袭的影响
%A 江跃全
%A 王志强
%A 蔡华荣
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1655
%X 摘要 目的 探讨芦荟苷对食管癌细胞系KESY70增殖、凋亡和侵袭的影响。方法 用不同浓度的芦荟苷处理食管癌细胞系KESY70。食管癌KESY70细胞随机分为5组：未处理组（KESY70）、对照组（DMSO）和芦荟苷（10、40、80 μmol/L）组。CCK-8检测细胞活力和增殖能力。流式细胞术分析细胞凋亡，Transwell检测细胞侵袭能力，蛋白印记法分析PCNA、Cleaved caspase-3和MMP-9的表达。结果 与DMSO组相比，40、80和120 μmol/L芦荟苷处理组细胞活力明显减弱（P<0.01）。40和80μmol/L的芦荟苷处理3 d后，芦荟苷组细胞增殖能力明显降低（P<0.05），芦荟苷组的细胞凋亡率明显高于DMSO组（P<0.05），侵袭能力受到明显抑制（P<0.05），PCNA、MMP-9蛋白的表达明显下降（P<0.05），Cleaved caspase-3表达明显升高（P<0.05）。结论 芦荟苷可抑制食管癌细胞系KESY70的增殖和侵袭，促进细胞凋亡
%K 芦荟苷
%K 食管癌
%K 增殖
%K 凋亡
%K 侵袭
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%U http://www.zlfzyj.com/CN/abstract/abstract9187.shtml